Endocrine Abstracts

Introduction: Adrenal insufficiency is a common problem in our country due to steroid abuse in various forms. In many occasions the patients even do not know about its side effects and consequences of non-prescribed usage. Many of them presents with sudden withdrawal and adrenal crisis. Many of them admits in Gastroenterology unit due to vomiting, some of them in Medical unit with unexplained fever, weakness, anaemia, etc. Many of them having subtle features of Iatrogenic Cush...

Introduction: Non-ketotic hyperglycaemic hyperosmolar (HHNK) coma is rare in children, is associated with high mortality rate. The incidence of this condition is reported to be increasing and considered to be related to increased prevalence in obesity and type 2 diabetes in children. Hyperglycaemic hyperosmolar syndrome (HHS) is rare in children. The pathophysiology and management of HHS is a distinct entity from diabetic ketoacidosis (DKA).Case report: ...

Introduction: The paediatric diabetes team in Leicester identified an unmet need for educating children about carbohydrate counting, following the initiation of most diagnosed patients on multiple dose insulin therapy (MDI). The team therefore started a new structured group education programme (SGEP) for children with type 1 diabetes (T1DM) called flexible adjustment of basal bolus (FABB) that has run since January 2007.Aims: To determine the effectivene...

Introduction: Malignant pheochromocytomas and paragangliomas (PPGLs) are rare, and knowledge of the natural history is limited. Material Methods: Data of 7 (7.6%) (out of 109) patients with malignant PPGLs referred to a Tertiary Centre of Endocrinology from Bucharest, Romania, were retrospectively collected. Follow-up ranged from 2004 to 2022. Demographic data, genetic status, site and size of primary tumor, biochemical activity, metastasis time (synchro...

Introduction: NICE NG18 recommends level 3 carbohydrate counting from diagnosis for CYP diagnosed with Type 1 Diabetes. Our unit introduced in-patient level 3 carb counting from day 1 in 2015 in response to an audit demonstrating sub-optimal control in the first year of treatment.Methods: We carried out a longitudinal study of HbA1c in paediatric patients during the first year of diagnosis in two time periods, before and after the introduction of carb co...

Our nurse-led testosterone replacement clinic in the Waikato Endocrine Service was the only clinic in New Zealand where specialised endocrine nurses established the use of and administered subcutaneous implants using testosterone pellets for hypogonadal men. Information gained through networking with nursing colleagues at the Annual Endocrine Nurses Society of Australasia (ENSA) symposia regarding the introduction of the depot injection Testosterone Undecanoate (Reandron™...

Case history: We report 7 weeks old with central diabetes insipidus, holoprosencephaly (HPE), immunodeficiency and severe colitis. She was first admitted with severe diarrhoea and hypernatremia. A diagnosis of central diabetes insipidus (CDI) was made and she was commenced on subcutaneous desmopressin (DDAVP). Her initial hypothalamic–pituitary axis (HPA) was normal (ACTH 10 ng/l, cortisol 635 nmol/l, GH 23 μg/l and TSH 3.30 μ/l). However repeated cortisols and ...

Glucokinase (GCK) serves as the blood glucose ‘sensor’ in pancreatic β-cells, being critically involved in transducing elevated blood glucose into increased insulin secretion. Inactivating GCK mutations cause a subtype of maturity onset diabetes of the young (MODY), whereas activating mutations are a rare cause of hyperinsulinaemic hypoglycaemia, usually presenting in infancy.We now describe the case of a 60-year-old woman who first presen...

Background: Klinefelter syndrome (KS) is the commonest sex chromosomal disorder. Characteristic features include male phenotype with hypogonadism and progressive testicular failure, gynaecomastia and learning difficulties. The association between mediastinal germ cell tumours (GCT-M) and KS is well established, with KS occurring in 20% of GCT-M patients and the reported incidence of GCT-M in KS being 1.5 per 1000 (Nichols, 1991). Genital anomalies are also known to be rarely o...

Introduction: Telehealth systems have become an alternative method to control chronic illnesses like diabetes. The aim of this study was to evaluate a telehealth system in patients with type 1 diabetes who have an optimized treatment with an insulin pump and real-time continuous glucose monitoring system.Research design and methods: Prospective, 1-year study of 15 patients with a continuous insulin infusion system and a real time glucose sensor. Three me...